{"id":6872,"date":"2026-01-22T18:35:58","date_gmt":"2026-01-22T17:35:58","guid":{"rendered":"https:\/\/www.ffrdiabete.org\/?p=6872"},"modified":"2026-01-22T19:08:03","modified_gmt":"2026-01-22T18:08:03","slug":"type-2-diabetes-cure-or-remission-can-it-happen","status":"publish","type":"post","link":"https:\/\/www.ffrdiabete.org\/en\/type-2-diabetes-cure-or-remission-can-it-happen\/","title":{"rendered":"PR\u00caT1D: screening earlier, acting fairer regarding type 1 diabetes!"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][vc_column_text css=&#8221;&#8221;]<\/p>\n<h3 style=\"text-align: center;\"><span style=\"color: #143877; font-family: Calibri, sans-serif; font-size: large;\"><strong><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-7059\" src=\"https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/PRET1D_Logo2-1024x683.png\" alt=\"\" width=\"324\" height=\"216\" srcset=\"https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/PRET1D_Logo2-1024x683.png 1024w, https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/PRET1D_Logo2-300x200.png 300w, https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/PRET1D_Logo2-768x512.png 768w, https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/PRET1D_Logo2.png 1536w\" sizes=\"auto, (max-width: 324px) 100vw, 324px\" \/>PR\u00caT1D &#8211; National project for the screening and management of presymptomatic type 1 diabetes, NEWLY SUPPORTED by the FFRD<\/strong><\/span><\/h3>\n<div>\n<div><\/div>\n<div><span style=\"color: #143877; font-family: Calibri, sans-serif; font-size: large;\"><strong>Background<\/strong><\/span><\/div>\n<div>\n<p class=\"p1\"><strong>The recently published French position statement by the SFD\/SFEDP<\/strong> provides an initial reference framework for the screening and management of preclinical type 1 diabetes (T1D) in relatives of individuals living with T1D. In addition, new <strong>ICD-10 diagnostic codes<\/strong> have been created for stage 1 (E10.A1) and stage 2 (E10.A2) T1D, suggesting that the management of preclinical T1D following screening is moving toward integration into routine clinical care <\/p>\n<p>The <em><strong>PR\u00caT1D <\/strong><\/em>study, <strong>promoted by the Fondation Francophone pour la Recherche sur le Diab\u00e8te (FFRD<\/strong> ), aims to <strong>remove 3 barriers<\/strong> to the development of this new patient pathway:<\/p>\n<p>&nbsp;<\/p>\n<div>\n<div><span style=\"color: #143877; font-family: Calibri, sans-serif; font-size: large;\"><strong>1) Access to screening<\/strong><\/span><\/div>\n<div>\n<p><em><strong>PR\u00caT1D<\/strong><\/em> proposes to simplify this step, which represents the largest volume of testing, and to <strong>move it outside hospitals and private practices<\/strong> by using <strong>capillary blood samples<\/strong> that can be <strong>self-collected at home<\/strong> and sent by mail to a centralized screening laboratory at Cochin Hospital. The four T1D-associated autoantibodies (IAA, GAD, IA-2, ZnT8) are measured there using a validated ADAP assay. Then, each <strong>screening result<\/strong> is communicated to the <strong>referring center<\/strong>, which informs the participant and organizes follow-up in accordance with the French position statement. An option for sample collection by healthcare professionals at participating centers is also available.   <\/p>\n<\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<div>\n<div>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-6898\" src=\"https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/2-SimplifierLeDepistage-1024x467.png\" alt=\"\" width=\"524\" height=\"239\" srcset=\"https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/2-SimplifierLeDepistage-1024x467.png 1024w, https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/2-SimplifierLeDepistage-300x137.png 300w, https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/2-SimplifierLeDepistage-768x350.png 768w, https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/2-SimplifierLeDepistage-1536x701.png 1536w, https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/2-SimplifierLeDepistage-2048x934.png 2048w\" sizes=\"auto, (max-width: 524px) 100vw, 524px\" \/><\/p>\n<p>&nbsp;<\/p>\n<div><span style=\"color: #143877; font-family: Calibri, sans-serif; font-size: large;\"><strong>2) Harmonized care treatment and management<\/strong><\/span><\/div>\n<div>\n<p class=\"p1\">The creation of a <strong>harmonized follow-up and care pathway<\/strong> for relatives with a positive screening test. Bu the end, <em><strong>PR\u00caT1D<\/strong><\/em> is proposing to simplify the process, using a <strong>digital health platform<\/strong> developed with startup Ailin. This platform will include 3 modules:  <\/p>\n<ul>\n<li class=\"p1\">a) a <strong>clinical dashboard<\/strong> for professionals, centralizing screening requests, results and follow-up with an individual, family and global vision, and proposing medical decision support algorithms;<\/li>\n<li class=\"p1\">b) a <strong>mobile application<\/strong> for patients, a tool for active engagement, facilitating direct patient\/expert center contact and offering information support and automated reminders;<\/li>\n<li class=\"p1\">c) a <strong>research registry<\/strong>, a pseudonymized database covering the prevalence\/natural history of preclinical T1DM, the acceptability\/feasibility of screening and the cost of screening\/follow-up.<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-6904\" src=\"https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/PRET1D-Ailin-1024x423.png\" alt=\"\" width=\"524\" height=\"217\" srcset=\"https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/PRET1D-Ailin-1024x423.png 1024w, https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/PRET1D-Ailin-300x124.png 300w, https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/PRET1D-Ailin-768x318.png 768w, https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/PRET1D-Ailin-1536x635.png 1536w, https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/PRET1D-Ailin-2048x847.png 2048w\" sizes=\"auto, (max-width: 524px) 100vw, 524px\" \/><\/p>\n<p>&nbsp;<\/p>\n<div>\n<div>\n<div>\n<div>\n<div><span style=\"color: #143877; font-family: Calibri, sans-serif; font-size: large;\"><strong>3) Long-term economic viability<\/strong><\/span><\/div>\n<div>\n<p class=\"p1\"><em><strong>PR\u00caT1D<\/strong><\/em> proposes to <strong>collect the data<\/strong> needed to discuss <strong>reimbursement<\/strong> options with the HAS using an interface with the <strong> <em>SFDT1<\/em> cohort<\/strong>, a <strong>study also promoted by the Fondation Francophone pour la Recherche sur le Diab\u00e8te (FFRD) since 2019<\/strong>. This interface will make it possible to track individuals who have progressed to clinical T1DM and compare them with those diagnosed without screening, at the time of clinical declaration and then at a distance: glycemic control and micro\/macroangiopathic complications via the <em><strong>SFDT1<\/strong><\/em>costs incurred\/avoided via SNDS data not available in other countries. <\/p>\n<\/div>\n<\/div>\n<div>\n<div>\n<p class=\"p1\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-6900\" src=\"https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/3-PRET1D_CollecterLesDonnees-1024x578.png\" alt=\"\" width=\"524\" height=\"296\" srcset=\"https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/3-PRET1D_CollecterLesDonnees-1024x578.png 1024w, https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/3-PRET1D_CollecterLesDonnees-300x169.png 300w, https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/3-PRET1D_CollecterLesDonnees-768x434.png 768w, https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/3-PRET1D_CollecterLesDonnees-1536x868.png 1536w, https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/3-PRET1D_CollecterLesDonnees-2048x1157.png 2048w\" sizes=\"auto, (max-width: 524px) 100vw, 524px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p class=\"p1\">This national pilot project (29 centers by 12\/25\/2025) will be rolled out in <strong>2 steps<\/strong>:<\/p>\n<div><em><strong><span style=\"color: #143877; font-family: Calibri, sans-serif; font-size: large;\">Step 1<\/span><\/strong><\/em><\/div>\n<div>\n<p class=\"p1\">On <strong>a small scale<\/strong>: 2,900 screenings\/year for around 12 months through the <strong>INNODIA Detect<\/strong> protocol, scheduled to start up in January 2026.<\/p>\n<div>\n<div><span style=\"color: #143877; font-family: Calibri, sans-serif; font-size: large;\"><em><strong>Step 2<\/strong><\/em><\/span><\/div>\n<div>\n<p class=\"p1\">On a <strong>larger scale<\/strong>: 7,500 screenings\/year for 4 years, through the <em><strong>PR\u00caT1D<\/strong><\/em>protocol, which will gradually follow.<\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<div>\n<div>\n<div>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-6902\" src=\"https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/4-DeploiementProgrammePilote-PRET1D-1024x407.png\" alt=\"\" width=\"524\" height=\"208\" srcset=\"https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/4-DeploiementProgrammePilote-PRET1D-1024x407.png 1024w, https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/4-DeploiementProgrammePilote-PRET1D-300x119.png 300w, https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/4-DeploiementProgrammePilote-PRET1D-768x305.png 768w, https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/4-DeploiementProgrammePilote-PRET1D-1536x611.png 1536w, https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/12\/4-DeploiementProgrammePilote-PRET1D-2048x815.png 2048w\" sizes=\"auto, (max-width: 524px) 100vw, 524px\" \/><\/p>\n<p>&nbsp;<\/p>\n<div>\n<p style=\"text-align: center;\"><a href=\"mailto:DT1.depistage.cch@aphp.fr\" target=\"_blank\" rel=\"noopener\"><strong>FOR MORE INFORMATION<\/strong><\/a><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p>[\/vc_column_text][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][vc_column_text css=&#8221;&#8221;] PR\u00caT1D &#8211; National project for the screening and management of presymptomatic type 1 diabetes, NEWLY SUPPORTED by the FFRD Background The recently published French position statement by the SFD\/SFEDP provides an initial reference framework for the screening and management of preclinical type 1 diabetes (T1D) in relatives of individuals living with T1D. In&hellip;<\/p>\n","protected":false},"author":2,"featured_media":7074,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-6872","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-non-classifiee","category-1","description-off"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>PR\u00caT1D: screening earlier, acting fairer regarding type 1 diabetes! - Fondation Francophone pour la Recherche sur le Diab\u00e8te - FFRD<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.ffrdiabete.org\/en\/type-2-diabetes-cure-or-remission-can-it-happen\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PR\u00caT1D: screening earlier, acting fairer regarding type 1 diabetes! - Fondation Francophone pour la Recherche sur le Diab\u00e8te - FFRD\" \/>\n<meta property=\"og:description\" content=\"[vc_row][vc_column][vc_column_text css=&#8221;&#8221;] PR\u00caT1D &#8211; National project for the screening and management of presymptomatic type 1 diabetes, NEWLY SUPPORTED by the FFRD Background The recently published French position statement by the SFD\/SFEDP provides an initial reference framework for the screening and management of preclinical type 1 diabetes (T1D) in relatives of individuals living with T1D. 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