{"id":1872,"date":"2023-08-25T10:57:26","date_gmt":"2023-08-25T08:57:26","guid":{"rendered":"https:\/\/ffrd.o3creative.fr\/research\/"},"modified":"2026-02-15T15:05:24","modified_gmt":"2026-02-15T14:05:24","slug":"research","status":"publish","type":"page","link":"https:\/\/www.ffrdiabete.org\/en\/research\/","title":{"rendered":"Research"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row][vc_column][ffrd_title title_level=&#8221;2&#8243; title_align=&#8221;title_align_left&#8221;]Research[\/ffrd_title][vc_empty_space height=&#8221;64px&#8221;][vc_column_text]<strong>The FFRD<\/strong> is proud to allocate <strong>over 80% of its expenses to research<\/strong> and is pleased <strong>to support high-quality research in francophone diabetology<\/strong> for over a decade.<\/p>\n<p>The <strong>basic research<\/strong> projects funded by the FFRD have addressed major themes related to both <strong>type 1 diabetes<\/strong> and <strong>type 2 diabetes<\/strong>, such as:<\/p>\n<ul>\n<li>The protection and replacement of pancreatic beta cells,<\/li>\n<li>Molecular mechanisms contributing to insulin resistance,<\/li>\n<li>Implications of other key organs: the liver, adipose tissue, intestine,<\/li>\n<li>The contribution of the microbiota to metabolic diseases.<\/li>\n<\/ul>\n<p>The <strong>clinical research<\/strong> projects, on the other hand, have addressed themes related to <strong>type 1<\/strong> and <strong>type 2<\/strong> diabetes, as well as <strong>gestational<\/strong> diabetes. They involve large multicenter cohort clinical studies, and their investigations are more mechanistic and\/or interventional.<\/p>\n<p>Several of the <strong>projects funded by the FFRD<\/strong> have specifically studied:<\/p>\n<ul>\n<li>The role of the intestine and the microbiota<\/li>\n<li>The role of epigenetics<\/li>\n<\/ul>\n<p>The research projects supported by <strong>the FFRD<\/strong> complement the projects led by the SFD (French Society of Diabetes). These are large-scale, internationally oriented projects that primarily meet five criteria: scientific originality, feasibility, financial adequacy, scientific relevance of the project and international competitiveness.[\/vc_column_text][\/vc_column][\/vc_row][vc_row height=&#8221;64px&#8221; el_id=&#8221;calls&#8221;][vc_column][vc_empty_space height=&#8221;64px&#8221;][ffrd_title title_level=&#8221;3&#8243; title_align=&#8221;title_align_right&#8221;]Call for Projects[\/ffrd_title][vc_empty_space height=&#8221;64px&#8221;][ffrd_appel][\/vc_column][\/vc_row][vc_row el_id=&#8221;submit&#8221;][vc_column][vc_empty_space height=&#8221;64px&#8221;][ffrd_title title_level=&#8221;3&#8243; title_align=&#8221;title_align_left&#8221;]Submiting a project[\/ffrd_title][vc_empty_space height=&#8221;64px&#8221;][vc_row_inner disable_element=&#8221;yes&#8221;][vc_column_inner width=&#8221;2\/3&#8243;][vc_column_text css=&#8221;&#8221;]<strong>\u203c\ufe0f NEXT CALL FOR PROJECTS IN 2026 \u203c\ufe0f<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p class=\"p1\">\ud83d\udcc6 See you next year to discover the new FFRD call for projects, its terms and conditions, as well as the lastest news from the Foundation&#8230; \ud83d\udc40<\/p>\n<p align=\"justify\">\u26a0\ufe0f opening of the call for projects in the first quarter of 2026&#8230;<\/p>\n<p>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/3&#8243;][vc_single_image image=&#8221;6473&#8243; img_size=&#8221;medium&#8221; alignment=&#8221;center&#8221; css=&#8221;&#8221; image_hovers=&#8221;false&#8221;][\/vc_column_inner][\/vc_row_inner][vc_row_inner disable_element=&#8221;yes&#8221;][vc_column_inner width=&#8221;2\/3&#8243;][vc_column_text css=&#8221;&#8221;]<strong>\u203c\ufe0f 2026 CALL FOR PROPOSALS ABOUT TO BE LAUNCHED\u00a0<\/strong><strong>\u203c\ufe0f<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p class=\"p1\">\ud83d\udcc6 Mark your calendars for <strong>February 16th<\/strong> to learn about its latest updates, details and discover the submission platform&#8230;<\/p>\n<p>&nbsp;<\/p>\n<p align=\"justify\">\u26a0\ufe0f <strong>Deadline on 30th April<\/strong> 11:59 PM&#8230;<\/p>\n<p>[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/3&#8243;][vc_single_image image=&#8221;5914&#8243; img_size=&#8221;medium&#8221; alignment=&#8221;center&#8221; css=&#8221;&#8221; image_hovers=&#8221;false&#8221;][\/vc_column_inner][\/vc_row_inner][vc_row_inner][vc_column_inner width=&#8221;2\/3&#8243;][vc_column_text css=&#8221;&#8221;]<strong>\u203c\ufe0f CALL FOR PROJECTS 2026 OPEN \u203c\ufe0f<br \/>\n<\/strong><\/p>\n<p align=\"justify\">Visit our <strong><a href=\"https:\/\/ffrdiabete.wiin.io\/fr\/\" target=\"_blank\" rel=\"noopener\">SUBMISSION PLATFORM<\/a><\/strong> to discover all details and requirements, create your account and submit your application.<\/p>\n<p>&nbsp;<\/p>\n<p align=\"justify\">\ud83d\udcd1 <a href=\"https:\/\/www.ffrdiabete.org\/wp-content\/uploads\/2025\/02\/FFRD_Formulaire_Soumission_AAP-2025.doc\" target=\"_blank\" rel=\"noopener\">Formulaire de soumission<\/a> : to download, complete and submit with your application file.<\/p>\n<p align=\"justify\">\ud83d\udcdd\u00a0<a href=\"https:\/\/www.ffrdiabete.org\/aidesoumission_candidature_ffrd_2026\/\" target=\"_blank\" rel=\"noopener\">Formulaire d\u2019aide \u00e0 la soumission<\/a> : to download in order to help you with your application submission.<\/p>\n<p>&nbsp;<\/p>\n<p align=\"justify\">\ud83d\udea6\u00a0<strong>You have until Thursday, April 30, 11:59 PM <\/strong>to submit your application file \ud83d\udea6<\/p>\n<p>&nbsp;<\/p>\n<p align=\"justify\"><strong>Direct access<\/strong><\/p>\n<p align=\"justify\">\u25b6\ufe0f \u00a0<a href=\"https:\/\/ffrdiabete.wiin.io\/fr\/register\" target=\"_blank\" rel=\"noopener\">Create your account<\/a> (1st connection)<\/p>\n<p align=\"justify\">\u25b6\ufe0f\u00a0 <a href=\"https:\/\/ffrdiabete.wiin.io\/fr\/login\" target=\"_blank\" rel=\"noopener\">Login<\/a> (once your account is created)<\/p>\n<p>&nbsp;<\/p>\n<p align=\"justify\"><em>\ud83d\udca1 You can log back in, update your information, and save your progress as many times as you wish.<\/em><\/p>\n<p>[\/vc_column_text][vc_empty_space]<style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">#default-btn-3b7a8bfa9cce8d9bd554f1d60efab18a.ico-right-side > i {\n  margin-right: 0px;\n  margin-left: 8px;\n}\n#default-btn-3b7a8bfa9cce8d9bd554f1d60efab18a > i {\n  margin-right: 8px;\n}<\/style><div class=\"btn-align-center\"><a href=\"https:\/\/ffrdiabete.wiin.io\/fr\/\" class=\"default-btn-shortcode dt-btn dt-btn-m link-hover-off \" target=\"_blank\" id=\"default-btn-3b7a8bfa9cce8d9bd554f1d60efab18a\" style=\"width:300px;\" rel=\"noopener\"><span>TO APPLY!<\/span><\/a><\/div>[\/vc_column_inner][vc_column_inner width=&#8221;1\/3&#8243;][vc_single_image image=&#8221;7161&#8243; img_size=&#8221;medium&#8221; alignment=&#8221;right&#8221; style=&#8221;vc_box_shadow_3d&#8221; css=&#8221;&#8221; image_hovers=&#8221;false&#8221;][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row el_id=&#8221;recipients&#8221;][vc_column][vc_empty_space height=&#8221;64px&#8221;][ffrd_title title_level=&#8221;3&#8243; title_align=&#8221;title_align_right&#8221;]Recipients[\/ffrd_title][vc_empty_space height=&#8221;64px&#8221;][vc_column_text css=&#8221;&#8221;]This year two candidates are recipients of the <strong>FFRD 2025 Research Grants<\/strong> :[\/vc_column_text][vc_empty_space][ffrd_laureats title_align_first=&#8221;title_align_right&#8221;][vc_empty_space]<style type=\"text\/css\" data-type=\"the7_shortcodes-inline-css\">#default-btn-d6c384cbf8e1b6bed69b607a350afa74.ico-right-side > i {\n  margin-right: 0px;\n  margin-left: 8px;\n}\n#default-btn-d6c384cbf8e1b6bed69b607a350afa74 > i {\n  margin-right: 8px;\n}<\/style><div class=\"btn-align-center\"><a href=\"#\" class=\"default-btn-shortcode dt-btn dt-btn-m link-hover-off archives_button \" id=\"default-btn-d6c384cbf8e1b6bed69b607a350afa74\"><span>View former recipients<\/span><\/a><\/div>[vc_row_inner el_class=&#8221;archives&#8221;][vc_column_inner][vc_empty_space height=&#8221;64px&#8221;][ffrd_title title_level=&#8221;4&#8243; title_align=&#8221;title_align_right&#8221;]FFRD&#8217;s receipients[\/ffrd_title][vc_empty_space height=&#8221;64px&#8221;][vc_column_text]Here are the former <strong>FFRD<\/strong>&#8216;s recipients:[\/vc_column_text][ffrd_laureats laureats_archives=&#8221;true&#8221; title_align_first=&#8221;title_align_left&#8221;][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row el_id=&#8221;talk-about&#8221;][vc_column][vc_empty_space height=&#8221;64px&#8221;][ffrd_title title_level=&#8221;3&#8243; title_align=&#8221;title_align_right&#8221;]Talking about FFRD[\/ffrd_title][vc_empty_space height=&#8221;64px&#8221;][vc_column_text]The recipients supported by the <strong>FFRD<\/strong> speak about it&#8230;[\/vc_column_text][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column][ffrd_title title_level=&#8221;4&#8243; title_align=&#8221;title_align_left&#8221;]Jacques BELTRAND[\/ffrd_title][vc_empty_space height=&#8221;16px&#8221;][vc_column_text css=&#8221;&#8221;]<\/p>\n<p style=\"text-align: right;\">Professeur of Pediatric Diabetology, Necker Enfants Malades Institute, Paris<\/p>\n<p>[\/vc_column_text][vc_row_inner content_placement=&#8221;middle&#8221; gap=&#8221;35&#8243;][vc_column_inner width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;5732&#8243; img_size=&#8221;large&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_circle_2&#8243; css=&#8221;&#8221; image_hovers=&#8221;false&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;3\/4&#8243;][vc_custom_heading text=&#8221;Study of the effects of strict glycemic control on cognitive functions in children with newly diagnosed Type 1 Diabetes&#8221; font_container=&#8221;tag:h4|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221; css=&#8221;&#8221;][vc_empty_space][vc_column_text css=&#8221;&#8221;]<em>Brain imaging data have highlighted the impact that glycemic variability can have on the development of gray and white matter in children\u2019s brains. While fluctuations between hypo- and hyperglycemia do not affect a child\u2019s psychomotor and intellectual development, significant glycemic variability could influence the acquisition of highly specific brain functions. New automated insulin delivery systems help reduce this variability. In adolescents, a study has shown that these systems can correct the neuropsychological impact of glycemic variability. Their use from the onset of the disease in children could therefore prevent delays in brain growth.<br \/>\nThe study we are conducting in \u00cele-de-France aims to determine the best treatment approach in the months following diagnosis to ensure that brain growth is comparable to that of children without type 1 diabetes. Study participants will be treated within weeks of diagnosis either with an insulin pump and glucose sensor or with new automated insulin delivery systems. Brain MRIs will be performed on patients at the beginning of the study and after 18 months of treatment, as well as on children of the same age without diabetes. <\/em><strong>This study, the first pediatric study supported by the FFRD<\/strong>, <strong>will provide important insights into the best care pathway for children in the months following diagnosis<\/strong><em>.<\/em>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column][ffrd_title title_level=&#8221;4&#8243; title_align=&#8221;title_align_right&#8221;]R\u00e9mi RABASA-LHORET[\/ffrd_title][vc_empty_space height=&#8221;16px&#8221;][vc_column_text]<\/p>\n<p style=\"text-align: left;\">MD, PhD, Directeur de recherche, Institut de Recherches Cliniques de Montr\u00e9al (ICRM)<\/p>\n<p>[\/vc_column_text][vc_row_inner content_placement=&#8221;middle&#8221; gap=&#8221;35&#8243;][vc_column_inner el_class=&#8221;vc_col-sm-push-9&#8243; width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;3039&#8243; img_size=&#8221;large&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_circle_2&#8243; image_hovers=&#8221;false&#8221;][\/vc_column_inner][vc_column_inner el_class=&#8221;vc_col-sm-pull-3&#8243; width=&#8221;3\/4&#8243;][vc_custom_heading text=&#8221;Identify dysglycemia in patients with cystic fibrosis (cystic fibrosis) with continuous blood glucose reading&#8221; font_container=&#8221;tag:h4|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221;][vc_empty_space][vc_column_text css=&#8221;&#8221;]<em>Patients with cystic fibrosis exhibit a broad spectrum of dysglycemia associated with an increased risk of accelerated clinical decline (weight loss and\/or lung function decline) and the risk of cystic fibrosis-related diabetes (CFRD). However, the current screening test, oral glucose tolerance test (OGTT), is associated with multiple issues, including patient and healthcare team acceptance, costs, etc. <\/em><strong>The support of the FFRD<\/strong><em> will enable us to conduct a study to determine whether continuous glucose monitoring simplifies the screening of DAFK and helps predict whether patients are at higher risk of weight loss and\/or lung function decline. <\/em><strong>These findings will provide better answers regarding the use and interpretation of continuous glucose monitoring in clinical practice<\/strong><br \/>\n<em>.<\/em><\/p>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column][ffrd_title title_level=&#8221;4&#8243; title_align=&#8221;title_align_left&#8221;]Soazig LE LAY[\/ffrd_title][vc_empty_space height=&#8221;16px&#8221;][vc_column_text css=&#8221;&#8221;]<\/p>\n<div class=\"page\" title=\"Page 1\">\n<div class=\"section\">\n<div class=\"layoutArea\">\n<div class=\"column\">\n<p style=\"text-align: right;\">INSERM, l\u2019Institut du Thorax de Nantes<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p>[\/vc_column_text][vc_row_inner content_placement=&#8221;middle&#8221; gap=&#8221;35&#8243;][vc_column_inner width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;5884&#8243; img_size=&#8221;large&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_circle_2&#8243; css=&#8221;&#8221; image_hovers=&#8221;false&#8221;][\/vc_column_inner][vc_column_inner width=&#8221;3\/4&#8243;][vc_custom_heading text=&#8221;Extracellular vesicles enriched in adiponectin: an innovative biotherapeutic approach for diabetes treatment&#8221; font_container=&#8221;tag:h4|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221; css=&#8221;&#8221;][vc_empty_space][vc_column_text css=&#8221;&#8221;]<\/p>\n<div class=\"page\" title=\"Page 1\">\n<div class=\"layoutArea\">\n<div class=\"column\">\n<p><em>Adiponectin (Adpn), an insulin-sensitizing adipokine, represents a promising target for treating cardiometabolic complications of type 2 diabetes (T2D). However, the development of Adpn-mimicking drugs has been hindered by challenges in obtaining its active oligomerized form (conversion of monomers into oligomers). Our research on extracellular vesicles (EVs) derived from adipose tissue has shown that they are naturally enriched with active Adpn. These vesicles enhance the bioavailability and prolong the stability of Adpn in circulation while preserving its insulin-sensitizing properties. <\/em><strong>Thanks to the support of the FFRD<\/strong>,<em> we will study the use of extracellular vesicles (EVs) enriched in adiponectin (Adpn) as \u201cmolecular taxis\u201d to deliver active forms of this adipokine and restore insulin sensitivity. <\/em><strong>This project paves the way for using extracellular vesicles (EVs) as biotherapeutics to better understand and treat complications of type 2 diabetes<\/strong><em><strong>.<\/strong><\/em><\/p>\n<\/div>\n<\/div>\n<\/div>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_empty_space][\/vc_column][\/vc_row][vc_row][vc_column][ffrd_title title_level=&#8221;4&#8243; title_align=&#8221;title_align_right&#8221;]Mariana IGOILLO-ESTEVE[\/ffrd_title][vc_empty_space height=&#8221;16px&#8221;][vc_column_text css=&#8221;&#8221;]<\/p>\n<div class=\"page\" title=\"Page 1\">\n<div class=\"section\">\n<div class=\"layoutArea\">\n<div class=\"column\">\n<p>Universite\u0301 Libre de Bruxelles, UCDR, Belgium<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<p>[\/vc_column_text][vc_row_inner content_placement=&#8221;middle&#8221; gap=&#8221;35&#8243;][vc_column_inner el_class=&#8221;vc_col-sm-push-9&#8243; width=&#8221;1\/4&#8243;][vc_single_image image=&#8221;2971&#8243; img_size=&#8221;large&#8221; alignment=&#8221;center&#8221; style=&#8221;vc_box_circle_2&#8243; css=&#8221;&#8221; image_hovers=&#8221;false&#8221;][\/vc_column_inner][vc_column_inner el_class=&#8221;vc_col-sm-pull-3&#8243; width=&#8221;3\/4&#8243;][vc_custom_heading text=&#8221;Study of the Contribution of TRMT10A Protein Deficiency and Small Non-Coding RNAs to the Pathogenesis of Type 1 Diabetes&#8221; font_container=&#8221;tag:h4|text_align:left&#8221; use_theme_fonts=&#8221;yes&#8221; css=&#8221;&#8221;][vc_empty_space][vc_column_text css=&#8221;&#8221;]<em>Type 1 diabetes (T1D) is an autoimmune disease that targets pancreatic beta cells. Its onset results from a complex interaction between genetic, immunological, and environmental factors, including enterovirus infections. Individuals with T1D require lifelong insulin therapy and face an increased risk of complications. To date, no treatment exists to cure or prevent the development of T1D. <\/em><\/p>\n<p><em>In our previous research, we demonstrated that mutations leading to a loss of function of the TRMT10A protein are responsible for juvenile diabetes, associated with microcephaly. We also found that the absence of TRMT10A causes the death of pancreatic beta cells, partly explained by an increase in the quantity of certain small non-coding RNAs in the cell. We now know that enterovirus infections also reduce the levels of TRMT10A. <\/em><strong>Thanks to the invaluable support of the FFRD<\/strong> <em>we have been able to establish various human cellular models of T1D and TRMT10A deficiency. These models will allow us to assess the extent to which the reduction in TRMT10A and the production of small non-coding RNAs contribute to the development of T1D, and to unravel the mechanisms leading to beta cell destruction. <\/em><strong>These findings could pave the way for new therapeutic approaches for this disease<\/strong><em>.<\/em><\/p>\n<p>[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][vc_empty_space][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row][vc_column][ffrd_title title_level=&#8221;2&#8243; title_align=&#8221;title_align_left&#8221;]Research[\/ffrd_title][vc_empty_space height=&#8221;64px&#8221;][vc_column_text]The FFRD is proud to allocate over 80% of its expenses to research and is pleased to support high-quality research in francophone diabetology for over a decade. The basic research projects funded by the FFRD have addressed major themes related to both type 1 diabetes and type 2 diabetes, such as: The&hellip;<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":2,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"class_list":["post-1872","page","type-page","status-publish","hentry","description-off"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Research - Fondation Francophone pour la Recherche sur le Diab\u00e8te - FFRD<\/title>\n<meta name=\"description\" content=\"The FFRD funds innovative research projects on diabetes and metabolic diseases? 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